K+ channels in biological processes: vascular K+ channels in the regulation of blood pressure
نویسندگان
چکیده
منابع مشابه
Role of Nitric Oxide and ATP-Sensitive K+ Channels in Regulation of Basal Blood Flow and Hypercapnic Vasodilatation of Cerebral Blood Vessels in Rabbit
Background: The mechanisms underlying cerebral hypercapnic vasodilatation are not fully understood. Objective: To investigate the role of nitric oxide (NO) and ATP-sensitive potassium (KATP) channels in basal blood flow regulation and hypercapnia-induced vasodilatation in rabbit cerebral blood vessels. Methods: The change in cerebral blood flow was measured by a laser Doppler flowmeter in 18 Ne...
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The dynamic regulation of blood pressure relies on the ability of small arteries and arterioles to finely adjust their diameters to maintain peripheral vascular resistance and cardiovascular homeostasis. At the level of the vascular smooth muscle cell (VSMC), contraction is mediated by elevations in cytosolic Ca concentration enabled by Ca conducting channels located intracellularly or in the p...
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Tolerance and dependence are two main problems that have limited morphine administration as an analgesic drug and they might be as a result of changes in the number and affinity of receptors, dysfunction of adenylate cyclase, impaired coupling between activated µ receptor and K+ channels, and changes in the K+ and Ca2+ channels. There are several reports concerning the role of some of these...
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Vascular tone and hence blood pressure are determined by the contractile state of vascular smooth muscle cells (VSMCs) within the blood vessel wall, which is regulated by intracellular calcium concentration ([Ca]i). Vasoconstrictors act through increasing [Ca]i as well as on the apparent calcium sensitivity of the contractile process in VSMCs, whereas relaxing factors have the opposite effect. ...
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ژورنال
عنوان ژورنال: Journal of Receptor, Ligand and Channel Research
سال: 2014
ISSN: 1178-699X
DOI: 10.2147/jrlcr.s36062